BDNF (I)rising from Exercise
نویسندگان
چکیده
منابع مشابه
Physical exercise neuroprotects ovariectomized 3xTg-AD mice through BDNF mechanisms.
Postmenopausal women may be more vulnerable to cognitive loss and Alzheimer's disease (AD) than premenopausal women because of their deficiency in estrogens, in addition to their usually older age. Aerobic physical exercise has been proposed as a therapeutic approach for maintaining health and well-being in postmenopausal women, and for improving brain health and plasticity in populations at hi...
متن کاملExercise induces BDNF and synapsin I to specific hippocampal subfields.
To assess the relationship between brain-derived neurotrophic factor (BDNF) and synapsin I in the hippocampus during exercise, we employed a novel microsphere injection method to block the action of BDNF through its tyrosine kinase (Trk) receptor and subsequently measure the mRNA levels of synapsin I, using real-time TaqMan RT-PCR for RNA quantification. After establishing a causal link between...
متن کاملThe aging hippocampus: interactions between exercise, depression, and BDNF.
Late adulthood is associated with increased hippocampal atrophy and dysfunction. Although there are multiple paths by which hippocampal deterioration occurs in late life, the authors discuss the evidence that a single nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene and age-related changes in BDNF protein or receptor expression contribute to hippocampal atrophy. The ...
متن کاملVoluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity.
We have investigated potential mechanisms by which exercise can promote changes in neuronal plasticity via modulation of neurotrophins. Rodents were exposed to voluntary wheel running for 3 or 7 days, and their lumbar spinal cord and soleus muscle were assessed for changes in brain-derived neurotrophic factor (BDNF), its signal transduction receptor (trkB), and downstream effectors for the acti...
متن کاملExercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway.
Exercise can improve cognitive function and has been linked to the increased expression of brain-derived neurotrophic factor (BDNF). However, the underlying molecular mechanisms driving the elevation of this neurotrophin remain unknown. Here we show that FNDC5, a previously identified muscle protein that is induced in exercise and is cleaved and secreted as irisin, is also elevated by endurance...
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ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2013
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2013.10.008